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Home \ Treatment & Care \ Treatment \ Supplements \ Creatine \ Bench \ Updates
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Scott, our resident chemist, has pointed out the destructive chain of events produced by free radicals. I have added some [high lighted comments] to the abstract on creatine below in an attempt to increase understanding. Any additional comments Scott has will add to our understanding of the importance of scavenging free radicals.
Researchers have a tendency to jump to conclusions. The published way of how things work may not be the complete story for creatine and other agents likely to treat HD. Creatine and fish oil may increase cell energy, be anti-oxidant and anti-inflammatory in an additive manner.
Of particular interest is that creatine does not decrease lipid peroxidation (fat break down, thought to be destructive for cells). Fish oil, does decrease lipid peroxidation. Vitamin E is thought to enhance the effect. This suggests that creatine fish oil and vitamin E are are additive for the treatment of HD.
It is now evident that the first generations to have effective treatment for HD are now restricted to those proactive folks that have learned and grown to treat themselves and their children. --Jerry 13-Jan-02
13 Jan 2002
Antioxidant Creatine: Direct antioxidant properties of creatine
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Lawler JM, et al. Redox Biology and Cell Signaling
Laboratory, Texas A&M University.
"To our knowledge, this is the first evidence that creatine has the potential to act as a direct antioxidant against aqueous radical and reactive species ions." |
Creatine is the most popular supplement proposed to be an ergogenic aid.
There is some evidence in the literature that creatine supplementation
increases lean body mass, muscular strength, and sprint power.
However, the efficacy of creatine has not been consistent, and the potential
mechanisms are unresolved. While limited evidence that suggests that creatine
could possess an antioxidant effect this has not been tested directly.
Because oxidants such as free radicals can affect muscle fatigue and protein
turnover, it is important to know whether creatine can neutralize free
radicals and other reactive oxygen species.
We tested the hypothesis that creatine would remove superoxide anions
(O(*-)(2)), peroxynitrite (OONO(-)), hydrogen peroxide, and lipid peroxides
(t-butyl hydroperoxide)[the most prevalent and destructive oxidants].
We also determined whether creatine displayed a significant antioxidant
scavenging capacity (ASC) using 2,2'-azino-bis(3-ethylbenzothiazolamine-6-sulfonic
acid) (ABTS(+))[free radical test agent] quenching as a marker. Creatine
did not significantly reduce levels of hydrogen peroxide or lipid peroxidation.
In contrast, creatine displayed a significant ability to remove ABTS(+),
O(*-)(2), and OONO(-)[all destructive free radicals] when compared with
controls. To our knowledge, this is the first evidence that creatine has
the potential to act as a direct antioxidant against aqueous radical and
reactive species ions.
Biochem Biophys Res Commun 2002 Jan 11;290(1):47-52 Lawler JM, et al. Redox Biology and Cell Signaling Laboratory, Texas A&M University
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