Q10 has no value in helping athletes. The following abstract is evidence that Q10 supplementation does increase plasma concentration of Q10 but not mitochondrial concentration of Q10 in muscle cells.
There is little reason to believe that HD patients will be helped by Q10 supplementation. At least this could be quickly resolved with mice. --Jerry 07/03/99
Svensson M, Malm C, Tonkonogi M, Ekblom B, Sjodin B, Sahlin K
Department of Physiology and Pharmacology, Karolinska Institute, Box 5626, S-114 86
Stockholm, Sweden. http://www.humankinetics.com/
[Medline record in process]
The aim of the present study was to investigate the concentration of ubiquinone-10 (Q10), at rest, in human skeletal muscle and blood plasma before and after a period of high-intensity training with or without Q10 supplementation. Another aim was to explore whether adenine nucleotide catabolism, lipid peroxidation, and mitochondrial function were affected by Q10 treatment. Seventeen young healthy men were assigned to either a control (placebo) or Q10-supplementation (120 mg/day) group. Q10 supplementation resulted in a significantly higher plasma Q10/total cholesterol level on Days 11 and 20 compared with Day 1. There was no significant change in the concentration of Q10 in skeletal muscle or in isolated skeletal muscle mitochondria in either group. Plasma hypoxanthine and uric acid concentrations increased markedly after each exercise test session in both groups. After the training period, the postexercise increase in plasma hypoxanthine was markedly reduced in both groups, but the response was partially reversed after the recovery period. It was concluded that Q10 supplementation increases the concentration of Q10 in plasma but not in skeletal muscle.
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