HDL Updates

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Peptide May Treat Huntington Disease
A first clinical sign of the mutant huntingtin gene is decreased blood flow. Researchers at USF have discovered a ...
Jerry Lampson
Posted to HDL: 13 Feb 2004

Toxin 3NPA and Huntington's Disease
HD researcher Mark Mattson recently invited Edward Calabrese to visit his lab to discuss the possibility of experiments that would ...
Jerry Lampson
Posted to HDL: 12 Dec 2003

Mosaicism In Huntington's Disease
This is the single most important follow up after the discovery of the mutant gene in 1993. If the expansion ...
Jerry Lampson
Posted to HDL: 16 Nov 2003

Organ Regeneration Sparks Huntington Hope
Massachusetts General Hospital researchers have harnessed newly discovered cells from an unexpected source, the spleen, to cure juvenile diabetes in ...
Jerry Lampson
Posted to HDL: 14 Nov 2003

Laser To Aid Huntington's Disease Research
Sandia nanolaser may help extend life-spans by rapidly analyzing possible neuroprotectant drugs. Preventing mitochondria from turning ugly may postpone Alzheimer’s, ...
Jerry Lampson
Posted to HDL: 23 Sep 2003

Small Molecules May Treat Huntington's Disease
Reata seeks to discover small molecules that will cross the blood brain barrier and disable the mutant hutingtin protein. ...
Jerry Lampson
Posted to HDL: 16 Sep 2003

Huntington's Misfolding Folding Protein
It is thought that the mutant Huntington's disease gene produces a protein that folds differently. Knowing just how the mutant ...
Jerry Lampson
Posted to HDL: 30 Aug 2003

ALS Protein Found in Huntington's Disease
The researchers have discovered the mutant SOD1 protein is also found in Parkinson's disease, Huntington's disease and Alzheimer's disease. ...
Jerry Lampson
Posted to HDL: 28 Aug 2003

Lab To Find Cure For Huntington's Disease
The new lab is part of a larger set of labs in the Health Profession Building that is scheduled to ...
Jerry Lampson
Posted to HDL: 21 Aug 2003

Researchers Discover Cause For Aging
Amazingly, if we perturb insulin/IGF-1 signaling and reproductive cells in the same animal, we end up with animals that live ...
Jerry Lampson
Posted to HDL: 16 May 2003

Vaccine May Target Huntington's Disease
UC Irvine researchers have discovered an important similarity in the causes of cell degeneration and death in diseases such as ...
Jerry Lampson
Posted to HDL: 17 Apr 2003

Towards the Conquest of Aging
A team led by the National Human Genome Research Institute today announced the discovery of the genetic basis of a ...
Jerry Lampson
Posted to HDL: 17 Apr 2003

Exercise Acts Like Drug To Improve Blood Flow
Exercise can act like a drug on the blood vessels, reducing the risk of heart disease by literally getting the ...
Jerry Lampson
Posted to HDL: 25 Jan 2003

Gene Protects Against Huntington's Disease
Researchers discover a natural defense against Huntington's disease ... ...
Jerry Lampson
Posted to HDL: 18 Dec 2002

Observing Proteins and Cells in the Wild
The bio-chemical process of life is at a frustratingly small scale. Researchers can not directly observe critical events in living ...
Jerry Lampson
Posted to HDL: 14 Dec 2002

Antipsychotics Affect Brain Derived Neutrophic Factor
Newer antipsychotic drugs may be more effective because in contrast to haloperidol (Haldol) they do not down-regulate a critical brain ...
Jerry Lampson
Posted to HDL: 13 Dec 2002

Cogent Leads to New Neuroscience
Cogent staff works without pay as doors close. New start has promise. ... ...
Jerry Lampson
Posted to HDL: 12 Dec 2002

New Neurons Have Lasting Effect
New neurons are continually generated in the adult hippocampus, but the important question, whether adult neurogenesis is transient or leads ...
Jerry Lampson
Posted to HDL: 06 Dec 2002

Calpain Activation Suspect In Huntington's Disease Progression
Increased apoptosis or caspase-3 cleavage is not supported in cell disfunction Huntingtin is a disease trigger. Normal and mutant huntingtin ...
Jerry Lampson
Posted to HDL: 05 Dec 2002

Hibernating Squirrels Provide Clues for Stroke, Parkinson’s
A compound that enables squirrels to hibernate may protect brain cells from the ravages of Parkinson’s disease. ... ...
*Adapted from press release 02 Nov 2002 by Jerry Lampson
Posted to HDL: 02 Nov 2002

Circadian Control of Neurogenesis.
There is now a rich literature showing that the ability to grow new brain cells is conserved across species. ...
Adapted from J Neurobiol 2002 Oct;53(1):90-5 by Jerry Lampson
Posted to HDL: 03 Oct 2002

Neural stem cells improve motor function in brain injuries
Transplants in animal models could translate into therapy for humans. ... ...
Adapted from University of Pennsylvania Medical Center press release by Jerry Lampson
Posted to HDL: 01 Oct 2002

New Drugs Protect Nerve Cells In Parkinson Mice
Two experimental drugs appear to prevent Parkinson’s disease-like brain damage and motor dysfunction. ... ...
Adapted from NIH press release 25-Sep-2002 by Jerry Lampson
Posted to HDL: 26 Sep 2002

The Common Path To Depression
Curing depression is not easy, but a new hypothesis for what causes depression could make future treatments more effective. ...

Posted to HDL: 04 Sep 2002

Stress Damages Brain
Stress blocks neurogenesis. The effects are reversible... ...
Julie Clayton, ICN reporter
Posted to HDL: 03 Sep 2002

Dehydroepiandrosterone (DHEA) Stimulates Neurogenesis
An endogenous steroid promotes neurogenesis. Possible treatment for Huntington's disease.... ...

Posted to HDL: 26 Aug 2002

Neurogenesis
The discovery of how brain cells die and how brain cells are replaced will change the focus of HD research.... ...
HDL Jerry Lampson
Posted to HDL: 24 Aug 2002

Mutant Huntingtin Does Not Kill Cells
Jerry's conjecture states that mutant huntingtin does not kill brain cells.... ...
Jerry Lampson
Posted to HDL: 14 Aug 2002

Unusual Collaboration Yields Leap In Disease Fight
Gene chips aids colaborating scientists in understanding Huntington's disease.... ...
Adapted from Naomi Aoki, Globe Staff, 07Aug02
Posted to HDL: 09 Aug 2002

Unusual Collaboration Yields Leap In Disease Fight
Gene chips aid colaborating scientists in understanding Huntington's disease.... ...
Adapted from Naomi Aoki, Globe Staff, 07Aug02
Posted to HDL: 08 Aug 2002

Proteins Downregulated by HD.
German researchers have discovered two more proteins, alpha 1-antitrypsin (AAT) and alphaB-crystallin (also called Heat Shock protein 27, (HSP 27)) ...

Posted to HDL: 17 Jul 2002

**Possible Vaccine For Huntington's Disease
Huntington's disease and Prion Brain disease are caused by proteins with repeated sequences. Repeated sequences can enable proteins to fold ...
Adapted from New York University Medical Center press release 03 Jul 2002
Posted to HDL: 03 Jul 2002

Xenon May Treat Huntington's Disease
Xenon's pharmacological properties... ...
Adapted from: Scientific Correspondence Nature 396, 324 (1998) FRANKS NP, et al.Biophysics Section, The Blackett Laboratory, Imperial College of Science, Technology and Medicine, Prince Consort Road, London
Posted to HDL: 08 Jun 2002

Lamp Gas May Protect Neurons
Lamp gas could aid brain patients... ...
Adapted from BBC health news 07 Jun 2002
Posted to HDL: 07 Jun 2002

Parkinson's Rat Cured
First Report of Stem Cell Signal of Intention to Become Specific Neuron; Cloned Cells Cure Parkinson’s in Rat Model... ...
Adapted from Rush-Presbyterian-St. Luke's Medical CenterNews Release 08-May-02
Posted to HDL: 08 May 2002

*Gene Silencing
It is just a worm but feeding it the RNA that makes a protein blocked the expression of that protein. ...
Adapted from Cold Spring Harbor Laboratory public release 14-Apl-02
Posted to HDL: 14 Apr 2002

Muscle Cells Rejuvenated
UT Southwestern researchers find protein transforms sedentary muscles to resemble exercised muscles... ...
Adapted from: University of Texas Southwestern Medical Center at Dallas press release 10-Apl-02
Posted to HDL: 11 Apr 2002

Tricking HD
Tricking Diseases Into Synthesizing Their Own Worst Enemies... ...
Inspired by Scripps Research Institute Press Release, 20-Mar-02
Posted to HDL: 20 Mar 2002

Digital Mouse Slices Speed Research
Now researchers can see what is really happening in those HD mice. Researchers are sure to find unexpected pathologies in ...
News Release Duke University Medical Center 01-Mar-02
Posted to HDL: 01 Mar 2002

Healthy Heart
Because HD folks have decreased brain circulation, a diet that preserves circulation is thought to be especially beneficial. The risk ...
Mayo Clinic, Public release date: 28-Feb-02
Posted to HDL: 28 Feb 2002

Protein Folding
Understanding the process will lead to chaperones that can rescue proteins from misfolding. This new study provides insights to how ...
Salk Institute News Release 27-Feb-02
Posted to HDL: 27 Feb 2002

Protein Folding
Understanding the process will lead to chaperones that can rescue proteins from misfolding. This new study provides insights to how ...
University of Pennsylvania Press Release
Posted to HDL: 26 Feb 2002

Cod Liver Oil
Science backs Cod Liver Oil as cure for arthritis... ...
Professor Caterson’s findings will be published in the journal "Arthritis and Rheumatism" later this year. i
Posted to HDL: 20 Feb 2002

Alpha-Lipoic Acid Boost
Dietary supplements make old rats youthful, may help rejuvenate aging humans, according to UC Berkeley study... ...
University of California - Berkeley
Posted to HDL: 18 Feb 2002

Enriched Life Slows HD
Environmental enrichment slows disease progression in R6/2 Huntington's disease mice..... ...
Ann Neurol, Hockly E, Bates GP, et al
Posted to HDL: 11 Feb 2002

Neurogenesis queried in diseased brain
Forget embryonic stem cell therapy for neurodegenerative diseases like Huntington's, says a New Zealand neurologist. The stem cells are already ...
Day 3 by Bea Perks
Posted to HDL: 05 Feb 2002

*Treating Nerve Cells
This is follow up, confirming research that neurons responsible for the early symptoms of HD are likely to be rescued ...
Press release, University of Houston
Posted to HDL: 18 Jan 2002

Caltech HD Progress
Now scientists at the California Institute of Technology have come one step closer to understanding how Huntington's disease develops and ...
Caltech press release
Posted to HDL: 15 Jan 2002