It is wonderful news that a food supplement, DHEA, also promotes neurogenesis. This is another weapon for our fight against HD. The following article should silence the sceptics about the benefits of DHEA. Search the net for sources and side effects. You may want to add DHEA to your supplements.-- Jerry

Posted to HDLighthouse: 26Aug02 HDL Update: DHEA Promotes Neurogenesis.

Cambridge scientists discovery Common steroid, DHEA, promotes neurogenesis. Endogenous DHEA decreases with age. Corticoids are markers of stress and the supression on neurogenesis. DHEA reverses the effects of corticoids.

Treating adult male rats with subcutaneous pellets of dehydroepiandrosterone (DHEA) increased the number of newly formed cells in the dentate gyrus of the hippocampus, and also antagonized the suppressive of corticosterone (40 mg/kg body weight daily for 5 days).

Neither pregnenolone (40 mg/kg/day), a precursor of DHEA, nor androstenediol (40 mg/kg/day), a major metabolite, replicated the effect of DHEA (40 mg/kg/day).

Corticosterone reduced the number of cells labelled with a marker for neurons (NeuN) following a 28-day survival period, and this was also prevented by DHEA. DHEA by itself increased the number of newly formed neurons, but only if treatment was continued throughout the period of survival.

Subcutaneous DHEA pellets stimulated neurogenesis in a small number of older rats ( approximately 12 months old).

These results show that DHEA, a steroid prominent in the blood and cerebral environment of humans, but which decreases markedly with age and during major depressive disorder, regulates neurogenesis in the hippocampus and modulates the inhibitory effect of increased corticoids on both the formation of new neurons and their survival.

Source: Eur J Neurosci 2002 Aug;16(3):445-53 Karishma KK, et al.

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