Welcome to the HDlighthouse! Getting started.
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New to the Huntington's Disease Lighthouse? Welcome to the HDlighthouse! Getting started.
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1 Jan 2009
Long term tetrabenazine use
In an Italian study, TBZ improved chorea for most patients; over time the magnitude of the benefit declined somewhat. 1 Jan 2009
Ethyl-EPA research report published
Ethyl-EPA is still in the research pipeline. 1 Jan 2009
Weight loss in HD
Weight loss in HD is a metabolic problem. 8 Dec 2008
The HD protein activates Nrf-2 responsive genes
A cell model study tells us more about the dysregulation of gene transcription in HD. 13 Oct 2008
Ethyl-EPA reduces cerebral atrophy in HD patients
Treatment with ethyl-EPA is associated with significant reduction in brain atrophy, particularly in the caudate and thalamus. 10 Oct 2008
A new HDAC inhibitor
Scripts Research Institute has developed a new HDAC inhibitor that partially restores normal gene transcription and improves movement and brain volume in the HD mice. 6 Oct 2008
Cytochrome c release as a therapeutic target
Methazolamide delays disease onset and significantly prolongs survival in the R6/2 mouse model of HD. 21 Sep 2008
Why did CEP-1347 fail in the Parkinson′s trial?
The possible reasons for the failure of CEP-1347 as a PD treatments are reviewed. 21 Sep 2008
mRNA levels of BDNF in rodent models of HD
mRNA levels of BDNF decline with disease progression in rodent models of HD and are restored to normal levels by CEP-1347. 19 Sep 2008
CEP-1347 restores BDNF expression in the R6/2 mice
CEP-1347 may be a candidate for the research pipeline of potential HD treatments. All Updates for Home |
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