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Creatine
  Creatine This section is devoted to what we currently know about creatine and what role creatine may play in the battle against Huntington's Disease.

You probably know of creatine as a supplement for muscle builders. But creatine has also been shown to have some interesting properties that have HD researchers excited. Read on for more details.

 

Creatine is a compound which has been found to slow disease progression and increase survival time in the R6/2 mouse model of HD. It has been found to be safe and well tolerated in Huntington's patients and is currently in clinical trials. Creatine addresses two sources of pathology in Huntington's Disease. Mitochondrial dysfunction results in energy impairment; creatine boosts cellular energy. In addition, oxidative stress occurs with aging and neurodegenerative disorders including Huntington's; creatine is an antioxidant.

For information about creatine from the Huntington Project review here: http://www.huntingtonproject.org/Portals/0/creatine.pdf

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Considering creatine as part of your proactive battle?
Read Dr. Goodman's:
• Approach to potential treatments.
• Pamphlet on Creatine.

10 Most Recent Updates
for: Creatine
5 Jul 2009
Creatine and CoQ10
Creatine and CoQ10 have additive effects in the R6/2 mice
 
16 Jan 2007
Creatine trials
Avicena is planning a phase II toxicology trial for its creatine product followed soon by a phase III trial.
 
30 Jan 2006
More evidence for creatine
A well done new study of creatine shows that it is safe, tolerable, and reduces a biomarker of DNA oxidative injury. ...
 
11 Jun 2005
HD Researchers Review Compounds ready for Clinical Trials
HD researchers discuss compounds that are are immediate candidates for human clinical trials in HD patients. ...
 
18 May 2005
The Creatine Timeline
Tabrizi and colleagues have now published results for their much awaited two year follow-up study of creatine. ...
 
29 Jan 2005
Creatine Supplementation Lowers Brain Glutamate Levels in HD patients
A long term trial of creatine is warranted, according to a recent study of brain metabolite levels in HD patients treated with the supplement. ...
 
All Updates for Creatine

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